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TABLE OF CONTENTS

INTRODUCTION

General information on Tribestan

1. CHEMICAL AND PHYSICAL PROPERTIES

2. PHARMACOLOGICAL STUDIES

2.1. Methods characterizing the stimulating effect on spermatogenesis
2.2. Effect on DNA synthesis in gonocytes
2.3. Effect on Leydig and Sertoli cells in the testes
2.4. Effect on concentration, motility and survival of spermatozoa
2.5. Effect on the sexual libido
2.6. Studies on serum concentration of the hormones from the hypophyseal-gonadal axis
2.7. Effect on the central nervous system
2.8. Effect on the cardiovascular system
2.9. Pharmacokinetic studies
2.10. Toxicological studies (G.Tanev, S.Zarkova, 1980)
2.10.1. Acute toxicity
2.10.2. Subacute toxicity
2.10.3. Chronic toxicity
2.11. Discussion of the results

3. CLINICAL STUDIES

3.1. Materials and methods
3.2. Results
3.3. Tolerance and side effects
3.4. Discussion of the results

4. CLINICAL STUDIES IN FEMALES WITH ENDOCRINE INFERTILITY OR POSTMENOPAUSAL SYNDROME

4.1. Parameters observed and evaluated
4.2. Results and discussion
4.3. Side effect in treatment with Tribestan
CONCLUSION

REFERENCES